Intoduction

The term limbic system is applied to a collection of brain structures found in all mammals which is involved with a variety of functions including epinephrine flow, emotion, behavior, motivation, long-term memory, and olfaction. Emotional life is largely housed in the limbic system, and it has a great deal to do with the formation of memories. The limbic system has great input on thirst, hunger, sexual behavior, and reward. Many drugs of abuse such as cocaine and amphetamines directly affect the structures of the limbic system. Perhaps the simplest way to understand the functions of the limbic system is to use the mnemonic “M-O-V-E.”

Structures of the Limbic System

Dog Brain Extraction

Fixation

Dissection

Molecular and Cellular Neuroscience

Neurotransmission

Neurotransmitters And Corresponding Receptors

Catecholamines

Dopamine

Dopamine Synthesis Dopamine Receptors

Class D1

Class D2

Dopamine Metabolism

Dopmanine Transporter Monoamine Oxidase Catachol-O-Methyl-Transferase Trace Amine Associated Receptor Veiscular Monoamine Transporter

Neural Pathways

Mesolimbic Pathway Mesocortical Pathway Nigrostriatal Pathway Tuberoinfundibular Pathway

Norepinephrine

Norepinephrine Synthesis Receptors

Alpha 1A Alpha 1B Alpha 1D Alpha 2A Alpha 2B Alpha 2C 1, 2 & 3

Norepinephrine Metabolism

Plasma Membrane Monoamine TransporterMonoamine OxidaseCatechol-O-Methyl-TransferaseTrace Amine Associated ReceptorVeiscular Monoamine Transporter

Neural Pathways

Monoamines

Serotonin (5-HT)SynthesisReceptors

5-HT1A 5-HT2A 5-HT2C 5-HT6

Monoamines Metabolism

Serotonin TransporterMonoamine OxidaseVesicular Monoamine TransporterNeural PathwaysOther Relevent Neurotransmiters

Glutamate

Behavioural Effects of Amphetamines

Amphetamine Effect on Neurotransmitters

Dopmanine Transporter Monoamine Oxidase Inhibitor VMAT Malfunction Catechol-O-Methyl-Transferase

Glutamate Effect

Dependance and Withdrawl

References


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Cat Fig.