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| '''The Role of cAMP in Skeletal Muscle Cell Adaptation''' Helena Pope Melanie Lean Josefin Jansson '''INTRODUCTION''' Cyclic adenosine monophosphate (cAMP) (see Figure 1 for structure) is a secondary messenger molecule, which helps to regulate numerous cell functions by way of signal transduction (Sjaastad ''et al'', 2003). G protein (guanylate nucleotide binding protein) activates the enzyme adenlyl cyclase, which stimulates the formation of cAMP from ATP (adenosine triphosphate). cAMP subsequently binds to and activates protein kinase A, which is a key enzyme in the pathway of signal transduction (see Figure 2) (Sjaastad ''et al'', 2003). Fluctuations in intracellular concentration of cAMP result in changes in cAMP dependent protein kinase activity (Korenman and Krall, 1977). The role of cAMP is extensive, much of which lies beyond the remit of discussion here (Rybalkin, ''et al'', 2003). The review will instead focus on the role of cAMP in skeletal muscle adaptation. |
Itt írjon a(z) cAMP_Muscle-ról/ről The Role of cAMP in Skeletal Muscle Cell Adaptation
Helena Pope Melanie Lean Josefin Jansson
INTRODUCTION
Cyclic adenosine monophosphate (cAMP) (see Figure 1 for structure) is a secondary messenger molecule, which helps to regulate numerous cell functions by way of signal transduction (Sjaastad et al, 2003). G protein (guanylate nucleotide binding protein) activates the enzyme adenlyl cyclase, which stimulates the formation of cAMP from ATP (adenosine triphosphate). cAMP subsequently binds to and activates protein kinase A, which is a key enzyme in the pathway of signal transduction (see Figure 2) (Sjaastad et al, 2003). Fluctuations in intracellular concentration of cAMP result in changes in cAMP dependent protein kinase activity (Korenman and Krall, 1977). The role of cAMP is extensive, much of which lies beyond the remit of discussion here (Rybalkin, et al, 2003). The review will instead focus on the role of cAMP in skeletal muscle adaptation.