Epilepsy and its treatment in dogs

Introduction

Epilepsy is the most common medical neurological disorder in dogs, and even due to anti-epileptic drugs, many dogs still suffer from seizures. It is important to study canine epilepsy and its cause, so a treatment can be offered. In this research paper we will address different causes, treatments and risk factors related to canine epilepsy.

Physiology of epilepsy

At a cellular and molecular level, the pathogenesis and pathophysiology of epilepsy are being studied thoroughly, but still little is known about the cause of epilepsies in dogs (Chandler, 2005). Epilepsy is defined as recurring seizures caused by an abnormality in brain function. These repetitive seizures are a result of the brain’s response to abnormal systemic metabolism, such as hypoglycemia, hypocalcemia, uremia, etc (Cui et al, 2017). The frequency and severity of seizures vary. Certain factors such as sleep deprivation, stress and hormonal factors show an increase in seizures (Forsgård et al, 2018). There are also recorded a correlation between the severity of a seizure and breed. Epilepsy is not terminal. Quality of life is the most important factor for a chronic medical disease like epilepsy. Euthanasia may be used as an option if the dog's quality of life is dramatically reduced or the financial and emotional burden exceeds the owner's limitations (Podell et al, 2016).

Types of canine epilepsies

Epilepsy can be inherited (genetic epilepsy), from structural defects in the brain (symptomatic epilepsy) or it can be caused by an unknown cause (idiopathic epilepsy) (“Epilepsy Research Initiative”, 2021). Identification of the type of epilepsy is important as it will tell what treatment is best suited.

Some gene mutations can be identified and help in the diagnosis of epilepsy. Most studies, however, have yet to identify causative gene mutations, implying that inheritance may involve several or many susceptibility genes and reflect additional environmental interactions (Ekenstedt et al, 2011). The symptomatic type of epilepsy can be caused either by abnormal brain structure, brain abnormalities such as tumors, head trauma or infectious diseases such as rabies or tetanus (Cui et al, 2017). Idiopathic is the most common type of epilepsy, and also the hardest type of epilepsy to identify as there is no direct cause for the seizures (Hülsmeyer et al, 2015).

Diagnosis and identification

For diagnosis, at least two unprovoked seizures are necessary, or one seizure paired with other symptoms, such as an acute head injury, past stroke, or an abnormality on an electroencephalogram (EEG) brain scan (Hülsmeyer et al, 2015). But this is only successful in some cases as most cases of epilepsy in dogs are from unknown causes.

Gene mutations

There are two types of canine epilepsies for which gene mutations have been identified: progressive myoclonic epilepsies and idiopathic epilepsy (Ekenstedt et al, 2011). So far, nine genes have been identified as being associated with progressive myoclonic epilepsies in a variety of dog breeds (Ekenstedt et al, 2011). Genetic idiopathic epilepsy research has been less effective, with only one relevant gene identified (Ekenstedt et al, 2011). For these ten kinds, genetic testing is available to help with diagnosis, prognosis, and breeding options (Ekenstedt et al, 2011). Process of elimination As mentioned much is still unknown about the cause of epilepsy in dogs. Therefore, it is also difficult to accurately diagnose. As with idiopathic epilepsy, it is a process of elimination (Unger et al, 2021). When all other neurological disorders resulting in seizures have been disproven the answer is usually idiopathic epilepsy.

Process of elimination

As mentioned much is still unknown about the cause of epilepsy in dogs. Therefore, it is also difficult to accurately diagnose. As with idiopathic epilepsy, it is a process of elimination (Unger et al, 2021). When all other neurological disorders resulting in seizures have been disproven the answer is usually idiopathic epilepsy.