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Adrenocortiotrop hormone normal function and Addison´s Disease ACTH is a adrenocorticotropic hormone produced in adrenal gland. The adrenal gland is paired and located near the kidneys. The gland consists of an outer cortex and an inner medulla, which produces steroid hormones and catecholamines, respectively. The cortex originates from mesoderm while the medulla has ectodermal origin and is a part of the sympathetic nervous system. The cortex consists of 3 zones or layers: 1. Zona glomerulosa – outermost layer Main site for mineralocorticoid production, mostly aldosterone 2. Zona fasciculata Main site for glucocorticoid production, mostly cortisol and corticosterone. 3. Zona reticularis – inner most layer Main site for aldosterone and estrogen production |
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